Covid: what is reactive vaccination, this new strategy studied against the epidemic?

In a context where the Covid epidemic continues to advance and where restrictive measures have been relaxed, vaccination remains the government’s main tool in the fight against the virus and its serious forms. Researchers from Inserm and the Sorbonne University have sought a strategy to further increase the vaccination rate in the population.

Researchers from Inserm and the Sorbonne University have published a study that models a strategy to further promote vaccination against Covid in the population. This strategy has a name: reactive vaccination.

The French population is widely vaccinated. As of March 22, Public Health France indicates that 79.4% of the population have a complete vaccination schedule and 80.8% have received at least one dose. However, pollution continues to increase, in a context of relaxation of restrictive measures.

Thus, in the face of a virus that continues to circulate strongly and in the face of more contagious variants, researchers are thinking of ways to continue promoting vaccination, a strategy on which the government essentially relies to fight the most serious forms of Covid. in particular. . .

What is this strategy about?

And reactive vaccination is one of them. The study carried out by Inserm researchers was published on March 17 in the journal nature communications. Their results show that “in most scenarios, with the same number of vaccine doses, a reactive strategy is more effective than other vaccination strategies to reduce the number of Covid-19 cases,” summarizes the institute’s press release.

So what is this strategy? It actually involves vaccination of “the entire entourage of cases at home and the workplace or school”. This strategy has already been used in other contexts, Inserm points out, in particular to deal with waves of meningitis.

This vaccination strategy is therefore opposed to a mass vaccination strategy, since it points more to the environment of a person who has been infected with the virus. And the results of the study show that this strategy is all the more effective the lower the vaccination coverage.

When is strategy relevant?

By way of comparison, according to the projections made, “In a context where vaccination coverage is around 45% and where viral circulation is high, the reduction in the number of cases in a two-month period increases from 10 to 16%”with reactive vaccination, versus a massive vaccination strategy.

On the contrary, if the vaccination coverage is higher, the strategy is of less interest, since, consequently, the environment of the infected person has a high probability of already being vaccinated. Inserm specifies that this approach could allow “to reach people who are not yet vaccinated and more easily convince them of the usefulness of the vaccine”.

Another projection, “is a tool that can also be reused and adapted in France in case another variant arises and where it is necessary to test the effectiveness of a reactive strategy to administer possible booster doses “, says Chiara Poletto, Inserm researcher and last study author.

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