symptoms, 44 cases in France, what is it?

NEW COVID VARIANT. One can be simultaneously infected with two variants of Covid at the same time. 44 cases of the XD variant (ex-Deltacron), the Delta/Omicron recombinant are confirmed in France. How do you know if you have two variants? A hybrid variant? Is more dangerous? What are the symptoms? We take stock.

[Mis à jour le 25 mars 2022 à 18h04] Can be infected simultaneously by two covid variants like with him Recombinant Delta/Omicron called variant XD (formerly “Deltacron”). “On March 21st, 44 sequences were detected in France, including 21 during Flash investigations” indicated Public Health France in its epidemiological update of March 24. “In that day, very little data available of the features of the XD variant, but investigations are ongoing Add the organism. Public Health France had confirmed for the first time cases of co-infections and recombinations of the Covid variant in France in his last variant risk analysis of Sars-Cov-2 in February. In the case of a recombination, we find the genetic material of the two variants – here Delta and Omicron – in the sampleor this co-infection has resulted in genetic recombination (“hybrid variant“). In January 2022, Leondios Kostrikis, a professor at the Department of Biological Sciences at the University of Cyprusannounced the discovery of a variant combining Delta and Omicron which he called “DeltacronWith his team, they had identified 25 Deltacron cases whose sequences were submitted to the Gisaid international database on January 7. How do you know if you have a coinfection ? Which is the situation in france ? which are the symptom ? It’s more dangerous ?

Definition: what is the XD variant?

In the case of recombination (as in the variant Delta+Omicron), two viruses infect the same cell and each one releases its genetic heritage (RNA). What new virus originated from two different viruses. “He has been assigned the XD lineage. and therefore is now the official name of this recombinant (formerly Deltacron). In that day, very little data available of the features of the XD variant, but investigations are ongoing. In the case of this recombinant, we either find the genetic material of the Delta and Omicron variants in the sampleor this co-infection has resulted in genetic recombination (“hybrid variant“).

How many cases of XD variant in France?

“On March 21st, 44 sequences were detected in France, including 21 during Flash surveys,” reports Public Health France on March 24. “Since February 18, a Recombinant Delta/Omicron (named XD variant) subject to close surveillance by Public Health France and the CNR Virus of respiratory infection. Most of its genome corresponds to delta variant but a large part of the S gene corresponds to the Omicron variant (sublineage BA.1)“said Public Health France. The organization had confirmed for the first time cases of coinfections and recombinations in France in their latest risk analysis of Sars-Cov-2 variants published on February 23.

These recombinants are difficult to detect because it is not known at first sight if we are dealing with a co-infection or a hybrid. This is high-flying work in genomics.me” indicates Professor Bruno Lina, virologist, in France Inter Tuesday, March 1, 2022.”The detected cases are currently under investigation.“says the head of the National Reference Center for Respiratory Infections Viruses in Lyon. It is in the framework of the sequencing carried out during the lightning surveys that the first cases of co-infections and recombinations appeared. “In France, Reinforced monitoring of Delta/Omicron coinfections has been launched to detect possible recombinants as soon as possible” added Public Health France. Before recalling the context: “Since the end of 2021, an Omicron wave has overlapped with a Delta wave in various regions of the world. This large-scale co-circulation of two variants increases the probability of co-infections and therefore of recombinants. Several suspected Delta/Omicron recombinants have recently been reported. in the UK, US and Australiaand others are under investigation“.

What are the symptoms of the XD variant?

“It is difficult to predict what the characteristics of such a recombinant will be compared to the two parental variants. and anticipate its impact on public health. That is why the recombinants of SARS-CoV-2 are under close international scrutiny“, indicates Public Health France. Today, the symptoms of an XD variant (or Deltacron) do not seem to be different from those established for the coronavirus:

  • stupid fatigue ;
  • Cough ;
  • Fever ;
  • Headache
  • muscle aches or body aches;
  • Throat pain ;
  • Runny nose ;
  • nausea and vomiting
  • Unpleasant breathing (more rarely)
  • Loss of taste and smell (more rarely)

What are the dangers for people infected with the XD variant?

These recombinants are subject to improved monitoringbecause they constitute major evolutionary events. It is difficult to predict what their characteristics will be in relation to the variants from which they derive, and therefore their impact on public health if they circulate in the population.” emphasizes Public Health France.

Sources:

Coronavirus : SARS-CoV-2 variant circulation, updated February 28, 2022, Public Health France.

– Flash surveys: evaluation of the circulation of SARS-CoV-2 variants in France, updated on February 28, 2022, Public Health France.

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